Incomplete fatty acid oxidation. The production and epimerization of 3-hydroxy fatty acids.

Studies of fatty acid oxidation. 3. The effects of acyl-CoA complexes on fatty acid oxidation.

The oxidation of fatty acids to acetoacetate or to carbon dioxide is affected by the presence of various aliphatic and aromatic acids. For example, benzoate inhibits acetoacetate formation from butyrate at low concentrations in guinea pig liver slices (Jowett & Quastel, 1935b) and in 'cyclophorase' preparations (Grafflin & Green, 1948). Benzoate also inhibits the oxidation of butyrate to C02 in...

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

Long-chain 3-hydroxydicarboxylic acids (3-OHDCAs) are thought to arise via beta-oxidation of the corresponding dicarboxylic acids (DCAs), although long-chain DCAs are neither readily transported into nor beta-oxidized in mitochondria. We thus examined whether omega-hydroxylation of 3-hydroxy fatty acids (3-OHFAs), formed via incomplete mitochondrial oxidation, is a more likely pathway for 3-OHD...

Fatty Acid Profles of Ram's Sperm after Removing Some Fatty Acid Sources from the Diets and Persistency of Fatty Acids in Sperm

Rat Liver Peroxisomes Catalyze the /3 Oxidation of Fatty Acids*

Peroxisomes were purified by differential and equilibrium density centrifugation from the livers of rats treated with clofibrate to enhance their peroxisomal system of fatty acid oxidation. These purified peroxisomes were tested for the presence of crotonase, /3-hydroxybutyryl-CoA dehydrogenase and thiolase using spectroscopic techniques that utilize the characteristic absorption bands of the a...

Oxidation of unsaturated fatty acids

Plant leaf systems have been incubated under various conditions with uniformly labeled oleic acid, and the breakdown products identified by gas-liquid chromatography. Young green leaves of the castor plant (Ricinis gibsonii) and of the field pea plant (Pisum sutiuum) catabolize oleic acid by an oxygen-requiring pathway to heptadec-8-enaI which is then dehydrogenated by an NAD-coupled mechanism ...